Connie is a psychology student. Tristan is a charming drifter. Both have signed up to a clinical trial for a new antidepressant super-drug. Sealed off from the outside world, the attraction between Connie and Tristan turns into deeper feelings as their doses get stronger. They've been warned of side effects – can they trust their feelings, or is this just a chemical romance? Winner of UK Critics' Circle Best New Play Award, Lucy Prebble's The Effect welcomes director David Cromer back to the Barrow Street Theatre, home of his hit shows Our Town and Tribes. In collaboration with Barrow Street Theatre and Jean Doumanian, this entirely American production marks the off-Broadway producing debut of The National Theatre of Great Britain. Previews for The Effect began on March 2, 2016 at the Barrow Street Theatre (27 Barrow Street), and officially opened on March 20, 2016.